Zelenko Treatment Protocol

Fundamental Principles
Treat patients based on clinical suspicion as soon as possible, preferably within the first 5 days of symptoms. Perform PCR testing, but do not withhold treatment pending results.
Risk Stratify Patients
- Low risk patient – Younger than 45, no comorbidities, and clinically stable
- High risk patient – Older than 45, younger than 45 with comorbidities, or clinically unstable
Treatment Options
Low-risk patients
- Supportive care with fluids, fever control, and rest
- Elemental Zinc 50mg 1 time a day for 7 days
- Vitamin C 1000mg 1 time a day for 7 days
- Vitamin D3 5000iu 1 time a day for 7 days
Dr. Zelenko Created Z-Stack all-in-one Pill with Zinc, Quercetin, C & D Vitamins.
Optional over the counter options
- Quercetin 500mg 2 times a day for 7 days or
- Epigallocatechin-gallate (EGCG) 400mg 1 time a day for 7 days

Moderate / High risk patients
- Elemental Zinc 50-100mg once a day for 7 days
- Vitamin C 1000mg 1 time a day for 7 days
- Vitamin D3 10000iu once a day for 7 days or 50000iu once a day for 1-2 days
- Azithromycin 500mg 1 time a day for 5 days or
- Doxycycline 100mg 2 times a day for 7 days
- Hydroxychloroquine (HCQ) 200mg 2 times a day for 5-7 days and/or
- Ivermectin 0.4-0.5mg/kg/day for 5-7 days Either or both HCQ and IVM can be used, and if one only, the second agent may be added after about 2 days of treatment if obvious recovery has not yet been observed etc.
