David A. Sinclair, A.O., Ph.D. is a tenured Professor in the Department of Genetics at the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School and serves as President of the Academy for Health and Lifespan Research.
He is best known for his work on understanding why we age and how to slow its effects. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995 and worked as a postdoctoral researcher at M.I.T. with Dr. Leonard Guarente where he co discovered a cause of aging for yeast as well as the role of Sir2 in epigenetic changes driven by genome instability.
In 1999, he moved to Harvard Medical School where he has been teaching aging biology and translational medicine for aging for the past 23 years. His early research was focused on the sirtuins, which are protein-modifying enzymes that respond to changing NAD+ levels and to caloric restriction (CR) with associated interests in epigenetics, energy metabolism, mitochondria, learning and memory, neurodegeneration, and cancer.